Sorrento Therapeutics logo

Sorrento Therapeutics

Senior Scientist in Antibody Drug Conjugation (ADC)

ADC – San Diego, California
Department ADC
Employment Type Full-Time
Minimum Experience Mid-level


Sorrento Therapeutics Inc. is a fast growing, clinical stage, antibody-centric, biopharmaceutical company developing new therapies to turn malignant cancers into manageable and possibly curable diseases. Sorrento's multimodal multipronged approach to fighting cancer is made possible by its' extensive immuno-oncology platforms, including key assets such as fully human antibodies ("G-MAB™ library"), clinical stage immuno-cellular therapies ("CAR-T"), intracellular targeting antibodies ("iTAbs"), antibody-drug conjugates ("ADC"), and clinical stage oncolytic virus ("Sephrevir®").
We attract smart people who play well with others. We're small enough for your ideas to make a big impact, and large enough to offer you opportunities to grow professionally at any stage of your career.

If you’re a quick learner, enjoy working in the biotech industry, and share our mission of providing ground-breaking impact to medicine, each other, and our patients, Sorrento Therapeutics is the place for you!

What we are looking for:

The successful candidate will prepare new ADCs using both general and proprietary bioconjugation methodology.  He or she must therefore demonstrate expertise in a variety of synthetic, analytical and purification techniques related to antibodies and antibody conjugates.  A particular emphasis is placed on a thorough mastery of analytical and preparative chromatography, especially hydrophobic interaction chromatography (HIC), ion exchange (IEX), and size-exclusion chromatography (SEC).

The successful candidate will be a detail-oriented individual who can manage and organize data on different projects.  He or she will be able to multi-task and problem solve while maintaining a clear sense of priorities and focus. The successful candidate must possess strong oral and written communication skills while working efficiently to satisfy strict timelines and deliverables.  As Levena is a team-oriented, multi-disciplinary environment, the successful candidate will be expected to play a leading role in interacting with the Synthetic Chemistry, Biology, Chemistry, Manufacturing and Controls (CMC), and Analytical Development teams. 


·       Ph.D. with 0-3 years or M.S. with 5+ years of experience in antibody bioconjugation, ADC development, or related research area, preferably in a pharmaceutical, biopharmaceutical or biotech organization.

·       Thorough knowledge and experience in analytical and preparative chromatography including, but not limited to, HIC, IEX, and SEC methods, along with TFF purification.


·       Must have strong problem solving, interpersonal, teamwork, project management and communication skills (oral & written).


·       Must be flexible, able to handle multiple projects simultaneously, and work efficiently to be able to satisfy specific timelines and deliverables.

·       The synthesis, purification, and characterization of ADCs and related biotherapeutic agents.


·       Possess a versatile technical mastery in antibody and ADC handling at multiple (microgram to gram) scales.


·       Maintain an expertise in analytical and preparative chromatography including, but not limited to, HIC, IEX, and SEC methods, in addition to Tangential Flow Filtration (TFF) processing.


·       The individual will be expected to communicate results both internally and externally through presentations and formal technical reports.


·       Maintain a legible, accurate, and detailed record of all relevant data and testing in the laboratory notebook, including specific protocols and procedures being utilized.


·       The individual will be required to lead efforts in method trouble shooting and the creation and/or revision of SOPs.


·       Perform laboratory work in a safe and compliant manner at all times.

Your reward: 

  • Be on the leading edge of immunotherapies for the treatment of cancer.
  • Earn a competitive salary that allows you to focus your attention on your passion for science.
  • A comprehensive benefits package including: medical, dental, vision, life and disability insurance, matching 401k, 10 paid holidays, and three-weeks’ PTO, plus stock options.


Principals only. Recruiters, please don't contact this job poster.

Sorrento Therapeutics, Inc. is an Equal Opportunity Employer

Thank You
Your application was submitted successfully.
Apply for this Job
  • Location
    San Diego, California
  • Department
  • Employment Type
  • Minimum Experience
  • Powered by